1128 Outcomes of Early and Late Decompressive Craniectomies in Contrast to Standard Medical Management in Patients with Traumatic Brain Injury with Refractory Intracranial Hypertension: Systematic Review and Meta-Analysis Study

Abstract Aim The meta-analysis explored the effectiveness of early and late decompressive craniectomies versus medical management in patients with refractory intracranial hypertension after sustaining traumatic brain injury. clinical outcomes analysed were grouped into 2 categories: favourable (good recovery moderate disability) unfavourable (death, vegetative state, severe disability). Intracranial pressure has been measured post-randomisation studies included. Method Google Scholar, Cochrane Medline search engines utilised for data collection ranging from 1999 until present. searched keywords encompassed: craniectomy, hypertension, management, Thereafter, was uploaded to Review Manager statistical analysis. Results Of 122 articles, 10 randomized controlled trials included meta-analysis. analysis yielded that relative risk (RR) overall mortality craniectomy group vs is 0.58 95% CI [0.41, 0.81] (P = 0.001). standardised mean difference (SMD) -2.59 [-3.72, -1.46] < 0.00001) between two groups. odds ratio considering (Glasgow Outcome Scale) undergoing surgery care 1.02 [0.57, 1.82] 0.95). Conclusions This demonstrates significantly reduces TBI management. Decompressive a greater potential treat than alone however more randomised are needed ascertain superiority these treatments future research.